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The goal of wire localization is to obtain a histologic diagnosis , or to perform complete excision of highly suspicious lesion , to excise CNB-proven tumors , or to remove residual suspicious calcifications following excision of malignant calcifications .

tumors following malignant calcifications

Wire localization performed using ultrasound guidance is more rapid and is better tolerated than mammographic localization.

US-guided wire localization can be accomplished if there is a residual lesion visualized sonographically, or if there is an accurately placed clip .


For patients found to have DCIS, complete excision of the entire breast lesion with appropriate margins is required for successful breast conservation therapy .

margins therapy
What is an appropriate margin?
Well I believe it might be the margin for error.
No it is not, it refers to the distance between a tumor and the edge of the surrounding tissue that’s removed along with it.

The achievement of excision margins that are negative for tumor involvement is a significant factor in the reduction of local tumor recurrence .

factor recurrence

The use of stereotactic CNB prior to planned excision of malignant micro-calcifications has decreased the incidence of finding positive margins at the time of excision . But still, 20 % of cases still have a positive histologic margin of excision (Stomper, 2000).

positive margin

The use of localization wires can be inserted mammographically into the breast to mark the site of the radiologic abnormality.

When an excision of a non-palpable breast lesion is performed, with or without retention of a localization wire, a specimen mammogram and pathologic assessment of tumor margins are required.


Whole specimen mammography is obligatory for clinically occult lesions excised under mammographic localization and is recommended for palpable lesions that are associated with micro-calcifications.

All specimens should be oriented by the surgeon . Specimen radiography is done to confirm the accurate removal of the mammographic abnormality and to guide the pathologist to sample the most appropriate area for histology . Visualization of the clip and/or foreign body material accompanying the clip helps the pathologist and the surgeon identify the prior biopsy site.

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Choosing the Best Stateto Incorporate

Choosing where to incorporate can be as important as choosing what type of Blue Floral Bardot Dress The Fashion Bible Clearance Websites Manchester Great Sale Sale Online Cheap Sale Hot Sale B2C05
. While there’s no legal requirement as to where your small business must incorporate, choosing the right jurisdiction is definitely a strategic issue that can provide benefits in the long run. For most small businesses incorporating in your home state makes the most sense, especially if you don’t engage in interstate commerce. If your small business, however, does engage in business across state lines, you should take certain factors into considerations such as how corporate taxes and laws vary between jurisdictions.

Home State

If you own a local small business and do not have plans to expand outside of your home state, incorporating at home usually makes the most sense. Generally, for every other state that you do business in, you will have to register and pay substantial fees as a foreign corporation. That means that if you incorporated in a different state, but only do business in your home state, you will likely be paying registration fees in the incorporating state as well as foreign corporation fees in your home state. In addition, you will likely have to hire a registered agent for service of process in every state that you do business.

Tax-Friendly State

Choosing a tax-friendly state can lead to huge potential savings for your small business. Nevada often tops the list as places to incorporate for tax considerations given that it has no taxes on corporate income, corporate shares, franchises, or personal income. Be aware though that most states require you to pay taxes on any income generated within that state. That means that if your small business was incorporated in Nevada, but you do business in both Nevada and New York, you will still have to pay New York taxes and fees. Here is a breakdown of corporate income taxes by state for 2016 by the Tax Foundation .

Corporate-Friendly State

You’ve probably heard the term “a Delaware corporation” before. Why do so many companies choose Delaware as a place to incorporate? It is because Delaware is widely known as the jurisdiction with the best business laws in the country. In addition to Delaware laws being very corporate-friendly, the court system, known as the Court of Chancery, is very sophisticated in business issues and is very effective in resolving issues. That means less legal costs for litigation that might take years longer elsewhere. Interestingly enough, many investors won’t even invest in a company that isn’t incorporated in Delaware or will require the company to reincorporate in Delaware. For a great summary of the benefits, take a look at this publication by the Buy Authentic Online Pink Demi leather cross body bag Pink amp; Purple Manu Atelier Visit SrGWn


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